Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655802 | 0.86 | PTGER4 (0.43) | PTGER4TP53PDE4BIDO1TDO2 | |
| SCHEMBL30353241 | 0.80 | PKM (0.40) | PTGER4MAPTSMN1; SMN2NPC1RXRA | |
| SCHEMBL29655815 | 0.77 | SMN1; SMN2 (0.47) | PTGER4SMN1; SMN2NPC1 | |
| SCHEMBL13761352 | 0.73 | MAPT (0.49) | LMNAMAPTHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL29655790 | 0.71 | PLK1 (0.46) | PTGER4TP53MAPTSMN1; SMN2NPC1 | |
| SCHEMBL25753076 | 0.69 | ALOX5 (0.42) | LMNAMAPTHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL15631138 | 0.67 | ALOX5 (0.51) | LMNAMAPTHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL19121353 | 0.67 | ALOX5 (0.44) | LMNAMAPTHPGDSMN1; SMN2ALOX5 | |
| SCHEMBL31474132 | 0.66 | KDM4E (0.41) | TP53IDO1TDO2MAPTHPGD | |
| SCHEMBL29655711 | 0.66 | SMN1; SMN2 (0.52) | HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138793-A1 | COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST | 小野薬品工業株式会社 | 2022-06-30 | — | — | WO | disclosed |
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |