Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 6/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381643 | 0.76 | AKT1 (0.65) | PRMT5HSD17B10DGAT2CHEK1AKT1 | |
| SCHEMBL28734098 | 0.74 | MAP4K4 (0.49) | PRMT5HSD17B10AKT1GPR119 | |
| SCHEMBL31368898 | 0.72 | P2RY12 (0.50) | GPR119RETEIF2AK4 | |
| SCHEMBL12820628 | 0.71 | PDE3B (0.51) | HSD17B10CHEK1AKT1GPR119 | |
| SCHEMBL30565902 | 0.71 | PDE3B (0.51) | HSD17B10CHEK1AKT1GPR119 | |
| SCHEMBL18163251 | 0.71 | PRMT5 (0.58) | PRMT5DGAT2GPR119 | |
| SCHEMBL29656913 | 0.70 | MAP4K4 (0.48) | GPR119RETEIF2AK4CYP11B2 | |
| SCHEMBL29461507 | 0.69 | PDE10A (0.54) | GPR119CYP11B2 | |
| SCHEMBL30592552 | 0.69 | HSD17B10 (0.47) | HSD17B10CHEK1AKT1L3MBTL1 | |
| SCHEMBL30592547 | 0.69 | HSD17B10 (0.47) | HSD17B10CHEK1AKT1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |