Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30592547 | 1.00 | HSD17B10 (0.47) | HSD17B10ESR2AKT1CHEK1NR1H2 | |
| SCHEMBL30592571 | 0.89 | HSD17B10 (0.50) | HSD17B10AKT1CHEK1KDM4EALDH1A1 | |
| SCHEMBL30592585 | 0.86 | HSD17B10 (0.47) | HSD17B10AKT1CHEK1KDM4EALDH1A1 | |
| SCHEMBL30565902 | 0.82 | PDE3B (0.51) | HSD17B10AKT1CHEK1NAMPTKDM4E | |
| SCHEMBL12820628 | 0.82 | PDE3B (0.51) | HSD17B10AKT1CHEK1NAMPTKDM4E | |
| SCHEMBL28734074 | 0.80 | HSD17B10 (0.48) | HSD17B10NAMPTKDM4EALDH1A1HPGD | |
| SCHEMBL29859618 | 0.80 | HSD17B10 (0.56) | HSD17B10AKT1CHEK1KDM4EALDH1A1 | |
| SCHEMBL30592586 | 0.78 | HSD17B10 (0.47) | HSD17B10AKT1CHEK1KDM4EALDH1A1 | |
| SCHEMBL28734098 | 0.74 | MAP4K4 (0.49) | HSD17B10AKT1NAMPTKDM4EALDH1A1 | |
| SCHEMBL25779773 | 0.73 | TRPV3 (0.45) | HSD17B10KDM4EALDH1A1HPGDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |