Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PDE8A | O60658 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22899862 | 1.00 | CHRNA7 (0.38) | CHRNA7PRMT5WDR77PIK3CDPIK3CA | |
| SCHEMBL28895432 | 0.91 | CHRNA7 (0.33) | CHRNA7PRMT5WDR77PIK3CDPIK3CA | |
| SCHEMBL28851079 | 0.76 | PIK3CD (0.40) | CHRNA7PIK3CDPIK3CAPDE8ACNR2 | |
| SCHEMBL29664318 | 0.76 | TRPV3 (0.35) | CHRNA7PIK3CDPIK3CACNR2HTR1A | |
| SCHEMBL28851189 | 0.76 | TRPV3 (0.35) | CHRNA7PIK3CDPIK3CACNR2HTR1A | |
| SCHEMBL28850945 | 0.72 | LRRK2 (0.36) | CHRNA7PIK3CDPIK3CACNR2HTR1A | |
| SCHEMBL22899867 | 0.72 | HTR1A (0.36) | CHRNA7PIK3CDPIK3CACNR2HTR1A | |
| SCHEMBL30019117 | 0.72 | HTR1A (0.36) | CHRNA7PIK3CDPIK3CACNR2HTR1A | |
| SCHEMBL20972281 | 0.71 | TRPV3 (0.40) | TRPV3 | |
| SCHEMBL27370606 | 0.71 | PDE8A (0.49) | CHRNA7PIK3CDPIK3CAPDE8ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118745185-A | Imidazopyrimidines as EED inhibitors and use thereof | 密歇根大学董事会 | 2024-10-08 | — | — | CN | disclosed |
| US-20240316051-A1 | A PHARMACEUTICAL COMBINATION AND USE THEREOF | ASCENTAGE PHARMA GROUP CORP LIMITED (CN) | 2024-09-26 | — | — | US | disclosed |
| CN-115212311-B | Pharmaceutical composition and application thereof | 苏州亚盛药业有限公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-114127073-B | Imidazopyrimidines as EED inhibitors and use thereof | 密歇根大学董事会 | 2024-05-31 | — | — | CN | disclosed |
| CN-115212311-A | Pharmaceutical composition and application thereof | 苏州亚盛药业有限公司 | 2022-10-21 | — | — | CN | disclosed |
| EP-3999510-A1 | IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF | The Regents Of The University Of Michigan (US) | 2022-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240316051-A1 | A PHARMACEUTICAL COMBINATION AND USE THEREOF | EED, EML4, KIT | CHRNA7 1719/4885PRMT5 2016/4885WDR77 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.