Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24469768 | 0.84 | SPR (0.34) | SPRPARP1GPR119ELANE | |
| SCHEMBL24469807 | 0.83 | P2RX3 (0.43) | F12SPRPARP1TNKS2PARP2 | |
| SCHEMBL29670401 | 0.81 | NAMPT (0.40) | F12DDB1CRBNSPRPARP1 | |
| SCHEMBL24484074 | 0.81 | NAMPT (0.40) | F12DDB1CRBNSPRPARP1 | |
| SCHEMBL22717415 | 0.80 | GPR119 (0.42) | F12SPRPARP1TNKS2PARP2 | |
| SCHEMBL22845220 | 0.79 | ABHD6 (0.39) | F12SPRPARP1TNKS2PARP2 | |
| SCHEMBL24469819 | 0.72 | SPR (0.34) | SPRPARP1ELANE | |
| SCHEMBL24469870 | 0.69 | PARP1 (0.37) | SPRPARP1NR1H2 | |
| SCHEMBL24469848 | 0.68 | P2RX3 (0.42) | F12PARP1TNKS2PARP2ADORA1 | |
| SCHEMBL26122508 | 0.67 | NR1H2 (0.41) | GPR119ESR2MAPTNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |