Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24484074 | 1.00 | NAMPT (0.40) | NAMPTF12GPR119KITP2RX3 | |
| SCHEMBL24469807 | 0.91 | P2RX3 (0.43) | F12P2RX3PARP1TNKS2PARP2 | |
| SCHEMBL24469902 | 0.86 | NAMPT (0.40) | NAMPTF12GPR119KITP2RX3 | |
| SCHEMBL22717415 | 0.84 | GPR119 (0.42) | F12GPR119P2RX3PARP1TNKS2 | |
| SCHEMBL22845220 | 0.83 | ABHD6 (0.39) | F12GPR119P2RX3PARP1TNKS2 | |
| SCHEMBL29670347 | 0.81 | F12 (0.40) | F12GPR119DDB1CRBNPARP1 | |
| SCHEMBL24469870 | 0.76 | PARP1 (0.37) | PARP1SPR | |
| SCHEMBL24469848 | 0.75 | P2RX3 (0.42) | F12P2RX3PARP1TNKS2PARP2 | |
| SCHEMBL24469985 | 0.75 | PARP1 (0.38) | GPR119PARP1SPR | |
| SCHEMBL24914388 | 0.70 | DDB1 (0.52) | F12KITDDB1CRBNGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |