Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.41 |
| ▸ | TUBB | P07437 | 4/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2967381 | 1.00 | HPGD (0.46) | HPGDAMY1ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2233185 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4ECYP1A1CYP1A2 | |
| SCHEMBL2233181 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4ECYP1A1CYP1A2 | |
| SCHEMBL12348660 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4ECYP1A1CYP1A2 | |
| SCHEMBL25322838 | 0.80 | AMY1A (0.53) | HPGDAMY1ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL16432077 | 0.78 | SHBG (0.39) | HPGDSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL16432078 | 0.78 | SHBG (0.39) | HPGDSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL23301134 | 0.76 | ERN1 (0.32) | — | |
| SCHEMBL24165966 | 0.75 | POLB (0.51) | HPGDSMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL17913419 | 0.75 | POLB (0.51) | HPGDSMN1; SMN2ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781445-B2 | Synthesis of indenoisoquinoliniums and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | PURDUE RESEARCH FOUNDATION | 2008-10-02 | — | — | US | disclosed |
| EP-1735281-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | Purdue Research Foundation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005089294-A2 | SYNTHESIS OF INDENOISOQUINOLINIUMS AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242692-A1 | Synthesis of Indenoisoquinoliniums and Methods of Use | INMT, QTRT1, QTRT2 | HPGD 729/4885AMY1A 4295/4885SMN1; SMN2 2906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.