Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR4 | P46093 | 3/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049607 | 1.00 | GPR4 (0.49) | GPR4PKLRGRM5JAK2JAK1 | |
| SCHEMBL1054762 | 0.87 | POLB (0.43) | GPR4GRM5JAK2JAK1OPRD1 | |
| SCHEMBL16049825 | 0.87 | PKLR (0.48) | GPR4PKLRGRM5OPRD1OPRK1 | |
| SCHEMBL7840748 | 0.86 | GRM5 (0.47) | GPR4GRM5JAK2JAK1OPRD1 | |
| SCHEMBL26081092 | 0.85 | IDH1 (0.49) | GPR4OPRD1OPRK1CYP11B2KDM1A | |
| SCHEMBL7838737 | 0.85 | GRM5 (0.48) | GPR4GRM5JAK2JAK1OPRD1 | |
| SCHEMBL1088021 | 0.82 | CYP46A1 (0.54) | PKLRGRM5JAK2JAK1OPRD1 | |
| SCHEMBL30585014 | 0.82 | CYP46A1 (0.54) | PKLRGRM5JAK2JAK1OPRD1 | |
| SCHEMBL13452533 | 0.82 | USP2 (0.41) | GPR4PKLRGRM5JAK2JAK1 | |
| SCHEMBL7511633 | 0.82 | BACE1 (0.45) | GPR4OPRD1OPRK1CYP11B2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523302-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2022-07-20 | — | — | EP | disclosed |