Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049607 | 0.82 | GPR4 (0.49) | CYP11B2GPR4OPRD1OPRK1ALOX15 | |
| SCHEMBL29686152 | 0.82 | GPR4 (0.49) | CYP11B2GPR4OPRD1OPRK1ALOX15 | |
| SCHEMBL1054762 | 0.81 | POLB (0.43) | CYP11B2GPR4OPRD1OPRK1MEN1 | |
| SCHEMBL16049825 | 0.81 | PKLR (0.48) | CYP11B2GPR4OPRD1OPRK1ALOX15 | |
| SCHEMBL30585014 | 0.81 | CYP46A1 (0.54) | OPRD1OPRK1TSHR | |
| SCHEMBL6619420 | 0.81 | BACE1 (0.49) | BACE1CYP11B2NOTCH1PDE10AOPRD1 | |
| SCHEMBL1088021 | 0.81 | CYP46A1 (0.54) | OPRD1OPRK1TSHR | |
| SCHEMBL26081092 | 0.79 | IDH1 (0.49) | CYP11B2PDE10AGPR4OPRD1OPRK1 | |
| SCHEMBL2951728 | 0.78 | OPRD1 (0.53) | OPRD1OPRK1ALOX15TSHRATM | |
| SCHEMBL513434 | 0.78 | CCR5 (0.42) | CYP11B2OPRD1OPRK1CCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905134-B1 | Piperidine derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-6107308-A | ANTIHISTAMINE; LEUTRIENE ANTAGONIST | KOWA CO., LTD. (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0905134-A1 | Piperidine derivatives as LTD4 and H1 antagonists | KOWA COMPANY, LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |