Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | GPR4 | P46093 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838737 | 0.90 | GRM5 (0.48) | GRM5JAK2JAK1OPRD1OPRK1 | |
| SCHEMBL7840907 | 0.89 | OPRD1 (0.40) | GRM5OPRD1OPRK1CYP11B2GPR119 | |
| SCHEMBL29686152 | 0.86 | GPR4 (0.49) | GRM5JAK2JAK1OPRD1OPRK1 | |
| SCHEMBL16049607 | 0.86 | GPR4 (0.49) | GRM5JAK2JAK1OPRD1OPRK1 | |
| SCHEMBL25225903 | 0.83 | GPR119 (0.49) | GRM5JAK2JAK1OPRD1OPRK1 | |
| SCHEMBL7849927 | 0.82 | OPRD1 (0.45) | OPRD1OPRK1GPR119ALDH1A1TACR1 | |
| SCHEMBL7840055 | 0.79 | JAK2 (0.42) | JAK2JAK1OPRD1OPRK1GPR119 | |
| SCHEMBL29845446 | 0.79 | GAA (0.38) | GRM5OPRD1ALDH1A1ALOX15KDM1A | |
| SCHEMBL7831085 | 0.79 | ALDH1A1 (0.50) | OPRD1OPRK1GPR119ALDH1A1KDM1A | |
| SCHEMBL7840954 | 0.78 | POLB (0.53) | ALDH1A1ALOX15TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |