Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29687180 | 0.82 | KIF11 (0.51) | TSHRRECQLPOLBRAB9AALDH1A1 | |
| SCHEMBL29687222 | 0.82 | KIF11 (0.51) | TSHRRECQLPOLBRAB9AALDH1A1 | |
| SCHEMBL29687055 | 0.79 | RAB9A (0.58) | TSHRRECQLPOLBRAB9AALDH1A1 | |
| SCHEMBL6875755 | 0.79 | RAB9A (0.58) | TSHRRECQLPOLBRAB9AALDH1A1 | |
| SCHEMBL29687046 | 0.78 | KIF11 (0.58) | TSHRRECQLRAB9ANPC1TP53 | |
| SCHEMBL1903330 | 0.77 | HSD17B10 (0.62) | TSHRHSD17B10RAB9ANPC1MAPT | |
| SCHEMBL6873113 | 0.77 | HSD17B10 (0.62) | TSHRHSD17B10RAB9ANPC1MAPT | |
| SCHEMBL28599104 | 0.76 | POLB (0.61) | TSHRRECQLPOLBUSP2ALOX15 | |
| Toluene SCHEMBL11581769 | 0.76 | TSHR (0.59) | TSHRRECQLPOLBRAB9ANPC1 | |
| SCHEMBL6918008 | 0.76 | POLB (0.66) | TSHRRECQLPOLBUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265083-B1 | SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE | ST JUDE CHILDRENS RES HOSPITAL (US) | 2022-07-06 | — | — | EP | disclosed |