Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22990718 | 1.00 | LMNA (0.37) | LMNAHTTTP53TDP1SMN1; SMN2 | |
| SCHEMBL718616 | 0.84 | TP53 (0.41) | LMNATP53TDP1ALDH1A1KMT2A | |
| SCHEMBL8759433 | 0.84 | ALDH1A1 (0.38) | TP53TDP1ALDH1A1 | |
| SCHEMBL1043931 | 0.78 | ALDH1A1 (0.38) | LMNAHTTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL31039285 | 0.78 | ALDH1A1 (0.38) | LMNAHTTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL9170444 | 0.76 | TP53 (0.35) | LMNATP53TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18266141 | 0.74 | NOS2 (0.52) | TP53TDP1 | |
| SCHEMBL31224615 | 0.74 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL24737373 | 0.74 | TRPA1 (0.34) | LMNAHTTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL26768907 | 0.71 | TP53 (0.36) | TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |