Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.57 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.57 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL800635 | 0.80 | LMNA (0.69) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL31703901 | 0.80 | LMNA (0.69) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL29479526 | 0.80 | PLOD2 (0.62) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL5332528 | 0.80 | PLOD2 (0.62) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL2938590 | 0.78 | ALDH1A1 (0.61) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL19223886 | 0.77 | LMNA (0.65) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL2424897 | 0.77 | LMNA (0.65) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Niacin SCHEMBL25222027 | 0.77 | ALDH1A1 (0.95) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Niacin SCHEMBL308682 | 0.77 | ALDH1A1 (0.95) | LMNACYP1A2CYP3A4TDP1ALDH1A1 | |
| SCHEMBL30773490 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028617-A | Heterocyclic inhibitors of CBP/EP300 and their use in the treatment of cancer | 基因泰克公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-109476641-B | Heterocyclic inhibitors of CBP/EP300 and their use in the treatment of cancer | 基因泰克公司 | 2022-07-05 | — | — | CN | disclosed |