Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23163760 | 0.90 | HSD11B1 (0.40) | HSD11B1HSD11B2KDM1ACCNA2CDK2 | |
| SCHEMBL29705644 | 0.87 | NFE2L2 (0.39) | HSD11B1HSD11B2MAP4K4CTSLCTSS | |
| SCHEMBL23163619 | 0.78 | NFE2L2 (0.36) | HSD11B1HSD11B2CTSLCTSSCTSK | |
| SCHEMBL23163735 | 0.73 | TBK1 (0.36) | CCNA2CDK2CCNA1XDHPDE4A | |
| SCHEMBL15821832 | 0.71 | MAP4K4 (0.47) | MAP4K4SLC6A4SLC6A3 | |
| SCHEMBL10351821 | 0.71 | NR1H4 (0.38) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18805036 | 0.71 | HCRTR2 (0.44) | HSD11B1 | |
| SCHEMBL18805051 | 0.71 | EP300 (0.44) | HSD11B1CCNA2CDK2CCNA1 | |
| SCHEMBL6546408 | 0.71 | PDE4B (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16462200 | 0.69 | MGAT2 (0.39) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555573-A | Prostaglandin E2(PGE2)EP4Receptor antagonists | 多曼治疗学公司 | 2022-05-27 | — | — | CN | disclosed |