SCHEMBL2972051

SCHEMBL2972051

CNC(=O)CN(C(=O)O)C1CCN(CCCC#Cc2ccc(Cl)cc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.44
C5AR1 P21730 1/20 0.44
UBE2M P61081 3/20 0.41
DCUN1D1 Q96GG9 3/20 0.41
HRH3 Q9Y5N1 4/20 0.39
OPRM1 P35372 1/20 0.39
ALOX5 P09917 1/20 0.38
HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2970172 0.94 HRH3 (0.43) DRD2C5AR1HRH3OPRM1
SCHEMBL2982101 0.87 DCUN1D1 (0.42) C5AR1UBE2MDCUN1D1
SCHEMBL2975704 0.85 C5AR1 (0.59) C5AR1UBE2MDCUN1D1HRH3OPRM1
SCHEMBL2973367 0.80 OPRM1 (0.58) C5AR1OPRM1
SCHEMBL2980105 0.80 SIGMAR1 (0.54) HRH3
SCHEMBL2980822 0.80 GRIN2B (0.44) HRH3
SCHEMBL2973375 0.79 CHRM2 (0.53) OPRM1
SCHEMBL3596491 0.77 DRD2 (0.50) DRD2UBE2MDCUN1D1HRH3
SCHEMBL3594337 0.77 HRH3 (0.47) DRD2HRH3
SCHEMBL2977489 0.74 KDM4E (0.53) OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7781590-B2 Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors SANOFI-AVENTIS (FR) 2010-08-24 US disclosed
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, CNR2 DRD2 1610/4885C5AR1 1847/4885UBE2M 3836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.