Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PPIA | P62937 | 2/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29730079 | 0.88 | DPP8 (0.35) | DPP8DPP9IDO1NAMPTL3MBTL1 | |
| SCHEMBL27202124 | 0.87 | NAMPT (0.35) | DPP8DPP9IDO1NAMPTL3MBTL1 | |
| SCHEMBL29730095 | 0.86 | MAPKAPK2 (0.36) | DPP8DPP9IDO1NAMPTNPC1 | |
| SCHEMBL24543134 | 0.86 | MAPKAPK2 (0.36) | DPP8DPP9IDO1NAMPTNPC1 | |
| SCHEMBL27202115 | 0.84 | ALDH1A1 (0.34) | RETNPC1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL27202134 | 0.81 | MAPK1 (0.43) | DPP8DPP9IDO1NPC1ALDH1A1 | |
| SCHEMBL24543133 | 0.81 | DPP8 (0.35) | DPP8DPP9IDO1NPC1RAB9A | |
| SCHEMBL29730163 | 0.81 | DPP8 (0.35) | DPP8DPP9IDO1NPC1RAB9A | |
| SCHEMBL29730109 | 0.81 | MAPK1 (0.43) | DPP8DPP9IDO1NPC1ALDH1A1 | |
| SCHEMBL29730116 | 0.80 | DPP8 (0.34) | DPP8DPP9IDO1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132450-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | ACADIA PHARMACEUTICALS INC. | 2024-04-25 | — | — | US | disclosed |
| EP-4263492-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | ACADIA Pharmaceuticals Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022129933-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Pandeia Therapeutics Limited (GB) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132450-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | GPR88, GPR65, GPR68 | RET 191/4885DPP8 3002/4885DPP9 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.