Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.82 |
| ▸ | PPP1R15A | O75807 | 1/20 | 0.82 |
| ▸ | MELK | Q14680 | 1/20 | 0.82 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | GRIN2D | O15399 | 11/20 | 0.62 |
| ▸ | GRIN3B | O60391 | 11/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.62 |
| ▸ | GRIN2C | Q14957 | 11/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872248 | 0.91 | NPSR1 (1.00) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| SCHEMBL29447252 | 0.91 | NPSR1 (1.00) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| Hydrochloric Acid SCHEMBL5703102 | 0.89 | NPSR1 (0.97) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| Guanabenz SCHEMBL3054917 | 0.83 | NPSR1 (1.00) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| SCHEMBL29445212 | 0.77 | GRIN2D (1.00) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| SCHEMBL15884162 | 0.77 | GRIN2D (1.00) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| Acetic Acid SCHEMBL21519488 | 0.76 | LMNA (0.61) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| Acetic Acid SCHEMBL21519491 | 0.73 | SMN1; SMN2 (0.56) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| SCHEMBL3446661 | 0.73 | LMNA (0.54) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B | |
| Bicarbonate SCHEMBL11884724 | 0.73 | ALDH1A1 (0.54) | NPSR1L3MBTL1PPP1R15AMELKPPP1R15B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024263569-A1 | REGULATION OF BUTYROPHILIN 2A1 (BTN2A1) | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2024-12-26 | — | — | WO | disclosed |
| US-20240115705-A1 | Regulation of Butyrophilin subfamily 3 member A1 (BTN3A1, CD277) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-04-11 | — | — | US | disclosed |
| EP-4288074-A1 | REGULATION OF BUTVROPHILIN SUBFAMILY 3 MEMBER A1 (BTN3A1, CD277) | The Regents of The University of California Santa Cruz (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022170344-A1 | REGULATION OF BUTVROPHILIN SUBFAMILY 3 MEMBER A1 (BTN3A1, CD277) | MARSON ALEXANDER (US) | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240115705-A1 | Regulation of Butyrophilin subfamily 3 member A1 (BTN3A1, CD277) | BTN3A1, BTF3, CD274 | ADRA2A 1586/4885ADRA2B 1714/4885ADRA2C 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.