Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089481 | 1.00 | ALOX5 (0.35) | ALOX5P2RX7TNKSTNKS2ALDH1A1 | |
| SCHEMBL30173074 | 0.74 | ALOX5 (0.37) | ALOX5 | |
| SCHEMBL29814481 | 0.72 | P2RX7 (0.39) | ALOX5P2RX7TNKSTNKS2ALDH1A1 | |
| SCHEMBL23089394 | 0.72 | P2RX7 (0.39) | ALOX5P2RX7TNKSTNKS2ALDH1A1 | |
| SCHEMBL1120946 | 0.72 | SMN1; SMN2 (0.41) | ALOX5P2RX7ALDH1A1 | |
| SCHEMBL12658930 | 0.72 | ALDH1A1 (0.39) | ALOX5P2RX7ALDH1A1KMT2A | |
| SCHEMBL23089550 | 0.70 | DRD2 (0.33) | OPRL1 | |
| SCHEMBL29814601 | 0.70 | DRD2 (0.33) | OPRL1 | |
| SCHEMBL31525294 | 0.67 | KMT2A (0.41) | ALOX5P2RX7ALDH1A1KMT2A | |
| SCHEMBL15459334 | 0.67 | ALOX5 (0.37) | ALOX5P2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874700-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-114945366-B | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-114945366-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2022-08-26 | — | — | CN | disclosed |
| EP-4027995-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |