SCHEMBL297366

SCHEMBL297366

O=c1[nH]c(-c2ccccc2)co1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.44
KDM4E B2RXH2 6/20 0.42
GAA P10253 3/20 0.42
MAPT P10636 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CTRC Q99895 1/20 0.42
HPGD P15428 3/20 0.41
HSD17B10 Q99714 3/20 0.41
ALDH1A1 P00352 2/20 0.41
PLA2G10 O15496 1/20 0.41
TAS2R38 P59533 1/20 0.41
CTSV O60911 1/20 0.40
LMNA P02545 1/20 0.40
TUBB4A P04350 1/20 0.40
TP53 P04637 1/20 0.40
TUBB P07437 1/20 0.40
CTSL P07711 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
TUBA1B P68363 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29144919 0.79 ERCC1 (0.46) NOTUMSMN1; SMN2KDM4EGAAMAPT
SCHEMBL7271565 0.79 GCGR (0.41) MAPTLMNACDK5CLK4NPY5R
SCHEMBL5210215 0.77 BRD4 (0.53) NOTUMKDM4EGAAHPGDALDH1A1
SCHEMBL9956357 0.77 NOTUM (0.47) NOTUMCLK4NPY5RNPC1RAB9A
SCHEMBL9954744 0.77 ALDH1A1 (0.49) NOTUMSMN1; SMN2KDM4EMAPTHPGD
SCHEMBL12309805 0.75 NOTUM (0.46) NOTUMSMN1; SMN2KDM4EMAPTTDP1
SCHEMBL1361621 0.75 NOTUM (0.46) NOTUMNPY5RSCN2ARAB9A
SCHEMBL905288 0.71 LMNA (0.50) SMN1; SMN2KDM4EGAAMAPTTDP1
SCHEMBL1361865 0.71 MEN1 (0.51) NOTUMKDM4EGAAMAPTPLA2G10
SCHEMBL1523603 0.71 TAS2R38 (0.47) NOTUMSMN1; SMN2KDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010677-B Preparation method of 4-phenyl-2 (3H) -oxazolone 扬州市普林斯医药科技有限公司 2024-05-03 CN claimed
CN-115010677-A Preparation method of 4-phenyl-2 (3H) -oxazolone 扬州市普林斯医药科技有限公司 2022-09-06 CN claimed
CN-109320554-B Novel method for synthesizing practical acetaminoacrylate compound 浙江海翔药业股份有限公司 2021-04-27 CN claimed
US-7193079-B1 Preparation of hymenialdisine derivatives and use thereof BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2007-03-20 US claimed
US-20070049575-A1 PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2007-03-01 US claimed
WO-2004103958-A2 PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF MICHIGAN STATE UNIVERSITY (US) 2004-12-02 WO claimed
US-20040235820-A1 Preparation of hymenialdisine derivatives and use thereof BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2004-11-25 US claimed
US-6461810-B1 DIAGNOSING GENETIC DISORDERS; GENETIC ENGINEERING PRINCETON UNIVERSITY 2002-10-08 US claimed
WO-1999024622-A1 TRIPLEX IN-SITU HYBRIDIZATION PRINCETON UNIVERSITY (US) 1999-05-20 WO claimed
EP-0832286-A4 MODIFIED NUCLEOTIDES FOR NUCLEIC ACID LABELING ONCOR INC (US) 1998-11-04 EP claimed
EP-0832286-A1 MODIFIED NUCLEOTIDES FOR NUCLEIC ACID LABELING ONCOR, INC. (US) 1998-04-01 EP claimed
US-5728526-A ANALYZING, HYBRIDIZING AND DETECTION ONCOR, INC. (US) 1998-03-17 US claimed
US-5684142-A Modified nucleotides for nucleic acid labeling ONCOR, INC. (US) 1997-11-04 US claimed
WO-1996041006-A1 MODIFIED NUCLEOTIDES FOR NUCLEIC ACID LABELING ONCOR, INC. (US) 1996-12-19 WO claimed
EP-0223177-B1 CARDIOTONIC PHENYL OXAZOLONES MERRELL DOW PHARMACEUTICALS INC. (US) 1992-08-19 EP claimed
US-4866085-A Cardiotonic phenyl oxazolones MERRELL DOW PHARMACEUTICALS INC. (US) 1989-09-12 US claimed
US-4728661-A Cardiotonic phenyl oxazolones MERRELL DOW PHARMACEUTICALS INC. (US) 1988-03-01 US claimed
EP-0223177-A1 Cardiotonic phenyl oxazolones MERRELL DOW PHARMACEUTICALS INC. (US) 1987-05-27 EP claimed
US-20250333533-A1 MACROPINOCYTOSING HUMAN ANTI-CD46 ANTIBODIES AND TARGETED CANCER THERAPEUTICS UNIV CALIFORNIA (US) 2025-10-30 US disclosed
US-4026700-A Charged particle modulator device and improved imaging methods for use thereof ADDRESSOGRAPH MULTIGRAPH CORPORATION (US) 1977-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040235820-A1 Preparation of hymenialdisine derivatives and use thereof NFKBIA, IKBKG, GSK3B NOTUM 1867/4885SMN1; SMN2 4429/4885KDM4E 1594/4885
US-20070049575-A1 PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF IDO2, CHEK2, NFKBIA NOTUM 1949/4885SMN1; SMN2 4454/4885KDM4E 1470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.