Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.56 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369831 | 0.82 | SLC22A6 (0.62) | PLA2G7ALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL11708241 | 0.79 | PLA2G7 (0.55) | PLA2G7ALDH1A1GAAMAPTL3MBTL1 | |
| SCHEMBL3830934 | 0.79 | PLA2G7 (0.55) | PLA2G7ALDH1A1MAPTRBBP9CYP1A2 | |
| SCHEMBL14419230 | 0.76 | KCNMA1 (0.60) | PLA2G7ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL22823848 | 0.76 | HPGD (0.59) | PLA2G7ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL4116720 | 0.76 | RAB9A (0.55) | PLA2G7ALDH1A1CA1CA2GAA | |
| SCHEMBL13606930 | 0.76 | PLA2G7 (0.58) | PLA2G7ALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL2975694 | 0.76 | RBBP9 (0.57) | PLA2G7ALDH1A1L3MBTL1RBBP9ADORA2A | |
| SCHEMBL3830939 | 0.76 | MAPT (0.57) | PLA2G7ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL1367377 | 0.75 | PLA2G7 (0.51) | PLA2G7ALDH1A1MAPTRECQLRBBP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281442-A1 | INHIBITORS OF DYRK AND PIM | COLD SPRING HARBOR LABORATORY (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159436-A1 | INHIBITORS OF DYRK AND PIM | COLD SPRING HARBOR LABORATORY (US) | 2022-07-28 | — | — | WO | disclosed |