Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975637 | 0.75 | MAOB (0.38) | MAOBLTB4RLTB4R2LMNAHTR2A | |
| SCHEMBL16412098 | 0.71 | LTB4R (0.41) | MAOBLTB4RLTB4R2POLBDRD2 | |
| SCHEMBL7169479 | 0.70 | LMNA (0.43) | MAOBLTB4RLTB4R2LMNACYP2C9 | |
| SCHEMBL14135291 | 0.68 | MAOA (0.42) | MAOBLMNAHTR2AHTR2CHRH1 | |
| SCHEMBL30883178 | 0.68 | MAOA (0.42) | MAOBLMNAHTR2AHTR2CHRH1 | |
| SCHEMBL8314144 | 0.66 | DRD2 (0.60) | HTR2AHTR2CHRH1DRD2DRD3 | |
| SCHEMBL350298 | 0.66 | DRD2 (0.60) | HTR2AHTR2CHRH1DRD2DRD3 | |
| SCHEMBL8314148 | 0.66 | DRD2 (0.60) | HTR2AHTR2CHRH1DRD2DRD3 | |
| SCHEMBL29960543 | 0.66 | DRD2 (0.60) | HTR2AHTR2CHRH1DRD2DRD3 | |
| SCHEMBL28863772 | 0.64 | MAOB (0.48) | MAOBLTB4RLTB4R2LMNADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776874-B2 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2010-08-17 | — | — | US | disclosed |