SCHEMBL29757455

SCHEMBL29757455

COC(=O)c1c(-c2ccc(Br)c(C=O)n2)nnn1C

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ADCY10 Q96PN6 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
ALDH1A1 P00352 4/20 0.32
KDM4E B2RXH2 1/20 0.31
HPGD P15428 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31
KMT2A Q03164 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23363295 1.00 ADCY10 (0.34) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL30862873 0.86 HCAR3 (0.31)
SCHEMBL29757487 0.85 NPC1 (0.36) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL23362584 0.85 NPC1 (0.36) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL23362847 0.82 CYP1A2 (0.32) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL29757475 0.82 CYP1A2 (0.32) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL23363685 0.81 ALDH1A1 (0.32) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL29757478 0.81 ALDH1A1 (0.32) ADCY10CYP1A2CYP2C19ALDH1A1KDM4E
SCHEMBL23362593 0.76 KDM4E (0.37) CYP1A2CYP2C19ALDH1A1KDM4EHTT
SCHEMBL29757474 0.76 KDM4E (0.37) CYP1A2CYP2C19ALDH1A1KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114728168-A Triazolecarbamate pyridylsulfonamides as LPA receptor antagonists and their use 吉利德科学公司 2022-07-08 CN disclosed