Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29761062 | 0.82 | TRPA1 (0.47) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL29761000 | 0.80 | RET (0.41) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL29616972 | 0.77 | LRRK2 (0.46) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL31267979 | 0.74 | CNR2 (0.49) | LRRK2HTTCNR2MAPTHDAC1 | |
| SCHEMBL29761078 | 0.72 | L3MBTL1 (0.52) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL3677097 | 0.71 | L3MBTL1 (0.46) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL29761040 | 0.71 | RET (0.41) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL5419659 | 0.71 | ROCK2 (0.44) | LRRK2RETPI4KAXDHPI4K2B | |
| SCHEMBL29761041 | 0.70 | AKT2 (0.43) | LRRK2PI4KAXDHPI4K2BPI4K2A | |
| SCHEMBL29993245 | 0.69 | XDH (0.55) | LRRK2RETPI4KAXDHPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425756-A | Adenosine receptor antagonist compounds and uses thereof | 日东制药株式会社 | 2023-07-14 | — | — | CN | disclosed |
| CN-114829363-A | Adenosine receptor antagonist compounds | 日东制药株式会社 | 2022-07-29 | — | — | CN | disclosed |