Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL29765454 | 1.00 | TP53 (0.41) | TP53TSHRPLA2G4BPTPN11RARB | |
| Bicarbonate SCHEMBL26607957 | 1.00 | TP53 (0.41) | TP53TSHRPLA2G4BPTPN11RARB | |
| Bicarbonate SCHEMBL26607969 | 1.00 | TP53 (0.41) | TP53TSHRPLA2G4BPTPN11RARB | |
| Bicarbonate SCHEMBL17911341 | 0.87 | TP53 (0.39) | TP53TSHRPLA2G4BPTPN11RARB | |
| Bicarbonate SCHEMBL29765552 | 0.86 | ADRB2 (0.32) | — | |
| Bicarbonate SCHEMBL26607968 | 0.86 | ADRB2 (0.32) | — | |
| SCHEMBL18844586 | 0.84 | APAF1 (0.38) | — | |
| SCHEMBL17916653 | 0.83 | LTA4H (0.40) | TP53TSHR | |
| Iodide SCHEMBL30731322 | 0.82 | LTA4H (0.39) | TP53TSHR | |
| Iodide SCHEMBL18824159 | 0.74 | FGFR1 (0.38) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12623250-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2026-05-12 | — | — | US | disclosed |
| US-12409473-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2025-09-09 | — | — | US | disclosed |
| US-20240351063-A1 | Carbene-Functionalized Composite Materials | THE UNIVERSITY OF WESTERN ONTARIO (CA) | 2024-10-24 | — | — | US | disclosed |
| US-20240173741-A1 | Carbene-Functionalized Composite Materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2024-05-30 | — | — | US | disclosed |
| US-11801528-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2023-10-31 | — | — | US | disclosed |
| US-20220258202-A1 | Carbene-Functionalized Composite Materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-08-18 | — | — | US | disclosed |
| US-11383266-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12623250-B2 | Carbene-functionalized composite materials | EPCAM, CAD, CTTN | TP53 800/4885TSHR 1119/4885PLA2G4B 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.