SCHEMBL2976754

SCHEMBL2976754

CNN(C(=O)O)C(CC=O)C1CCN(CCCc2cc(-c3ccc(Cl)cc3)no2)CC1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
DRD2 P14416 12/20 0.39
DRD4 P21917 12/20 0.39
DRD3 P35462 12/20 0.39
JAK2 O60674 1/20 0.38
ALDH1A1 P00352 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
USP30 Q70CQ3 2/20 0.38
F10 P00742 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2981410 0.95 LMNA (0.40) LMNAPOLBDRD2DRD4DRD3
SCHEMBL2972024 0.90 DRD2 (0.42) LMNAPOLBDRD2DRD4DRD3
SCHEMBL2981437 0.87 MAPT (0.39) LMNAPOLBDRD2DRD4DRD3
SCHEMBL2965452 0.83 NPC1 (0.37) POLBDRD2DRD4DRD3ALDH1A1
SCHEMBL2975031 0.78 ARG1 (0.43) F10
SCHEMBL3594360 0.78 DRD2 (0.45) LMNAPOLBDRD2DRD4DRD3
SCHEMBL2976745 0.77 JAK2 (0.42) LMNAPOLBDRD2DRD4DRD3
SCHEMBL2970171 0.77 TEAD1 (0.45)
SCHEMBL2980824 0.76 HRH3 (0.39) DRD2
Hydrochloric Acid SCHEMBL2971262 0.76 TEAD1 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7781590-B2 Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors SANOFI-AVENTIS (FR) 2010-08-24 US disclosed
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, CNR2 LMNA 3216/4885POLB 2201/4885DRD2 1610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.