Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977145 | 0.88 | IRAK4 (0.50) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL5432823 | 0.85 | MMP2 (0.55) | FADS1MMP2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8341665 | 0.83 | FADS1 (0.41) | IRAK4FADS1MMP2ALDH1A1KDM4E | |
| SCHEMBL17786089 | 0.82 | IRAK4 (0.44) | IRAK4FADS1MMP2ALDH1A1KDM4E | |
| SCHEMBL20425249 | 0.81 | ALDH1A1 (0.49) | IRAK4FADS1MMP2ALDH1A1KDM4E | |
| SCHEMBL6951207 | 0.81 | KDM4E (0.55) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL458410 | 0.81 | IRAK4 (0.44) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL8340013 | 0.81 | HTT (0.38) | IRAK4FADS1MMP2ALDH1A1KDM4E | |
| SCHEMBL1832020 | 0.81 | IRAK4 (0.44) | IRAK4MMP2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30797325 | 0.81 | IRAK4 (0.44) | IRAK4ALDH1A1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |