Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431626 | 0.88 | — | — | |
| SCHEMBL10759 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL29424070 | 0.86 | MAPK1 (0.46) | KMT2AMAPK1PARP1KDM4EALDH1A1 | |
| SCHEMBL2446692 | 0.86 | MAPK1 (0.46) | KMT2AMAPK1PARP1KDM4EALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL8971987 | 0.86 | MAPK1 (0.46) | KMT2AMAPK1PARP1KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL29858985 | 0.80 | L3MBTL1 (0.40) | MAPK1PARP1KDM4EALDH1A1GLA | |
| Formic Acid SCHEMBL27894493 | 0.75 | ALDH1A1 (0.50) | KMT2AKDM4EALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL28135793 | 0.74 | QPCT (0.49) | MAPK1KDM4EALDH1A1GLAGAA | |
| SCHEMBL1809684 | 0.74 | KDM4E (0.33) | MAPK1PARP1KDM4EALDH1A1GLA | |
| Benzimidazole SCHEMBL28874195 | 0.73 | KDM4E (0.47) | KMT2APARP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250288595-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORP (US) | 2025-09-18 | — | — | US | disclosed |
| US-12318392-B2 | Tropomyosin-related kinase (trk) inhibitors | GENZYME CORPORATION (US) | 2025-06-03 | — | — | US | disclosed |
| US-20240189322-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | GENZYME CORPORATION | 2024-06-13 | — | — | US | disclosed |
| US-11878024-B2 | Tropomyosin-related kinase (Trk) inhibitors | GENZYME CORPORATION (US) | 2024-01-23 | — | — | US | disclosed |
| US-11406644-B2 | Tropomyosin-related kinase (TRK) inhibitors | GENZYME CORPORATION (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12318392-B2 | Tropomyosin-related kinase (trk) inhibitors | NTRK1, NGF, NTRK2 | KMT2A 2861/4885MAPK1 199/4885PARP1 2089/4885 |
| US-11406644-B2 | Tropomyosin-related kinase (TRK) inhibitors | NTRK1, NGF, NTRK2 | KMT2A 2861/4885MAPK1 199/4885PARP1 2089/4885 |
| US-20240189322-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | NTRK1, NGF, NTRK2 | KMT2A 2861/4885MAPK1 199/4885PARP1 2089/4885 |
| US-11878024-B2 | Tropomyosin-related kinase (Trk) inhibitors | NTRK1, NGF, NTRK2 | KMT2A 2861/4885MAPK1 199/4885PARP1 2089/4885 |
| US-20250288595-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | NTRK1, NGF, NTRK2 | KMT2A 2861/4885MAPK1 199/4885PARP1 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.