Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412224 | 0.81 | DAO (0.45) | DAOJAK2BTKFEN1MEN1 | |
| SCHEMBL14691916 | 0.79 | HDAC6 (0.47) | ADORA3ADORA2AADORA2BADORA1DAO | |
| SCHEMBL13954881 | 0.79 | DAO (0.64) | ADORA3ADORA2AADORA2BADORA1DAO | |
| SCHEMBL6395773 | 0.74 | ADORA2B (0.41) | ADORA3ADORA2AADORA2BADORA1FEN1 | |
| SCHEMBL25150492 | 0.72 | PARP1 (0.45) | DAOFEN1MEN1ALDH1A1KMT2A | |
| SCHEMBL5033267 | 0.71 | GPR3 (0.52) | ADORA3ADORA2AADORA2BADORA1DAO | |
| SCHEMBL7295311 | 0.70 | JAK2 (0.42) | JAK2BTKALDH1A1PARP1LMNA | |
| SCHEMBL25920578 | 0.69 | JAK2 (0.41) | DAOJAK2BTKFEN1ALDH1A1 | |
| Benzene SCHEMBL28335868 | 0.69 | ADORA3 (0.50) | ADORA3ADORA2AADORA2BADORA1DAO | |
| SCHEMBL3580909 | 0.69 | JAK2 (0.42) | DAOJAK2BTKALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-28 | — | — | US | disclosed |
| CN-110312713-B | Process for preparing tetrahydrocarbazole carboxamide compounds | 百时美施贵宝公司 | 2022-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11591314-B2 | Process for preparing tetrahydrocarbazole carboxamide compound | CYP2C8, CYP3A7, PARP8 | ADORA3 1486/4885ADORA2A 1690/4885ADORA2B 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.