Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GPR3 | P46089 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311183 | 0.71 | ALKBH5 (0.63) | JAK2BTKTSHRKDM4ELMNA | |
| SCHEMBL29785322 | 0.69 | ADORA3 (0.46) | JAK2BTKLMNAMAPK1ALDH1A1 | |
| SCHEMBL3580909 | 0.69 | JAK2 (0.42) | JAK2BTKTSHRKDM4ELMNA | |
| SCHEMBL24050350 | 0.67 | GPR3 (0.58) | KDM4ELMNAHTTHSD17B10ALDH1A1 | |
| SCHEMBL11331884 | 0.64 | NPC1 (0.47) | JAK2BTKKDM4ELMNAALDH1A1 | |
| SCHEMBL7295311 | 0.64 | JAK2 (0.42) | JAK2BTKKDM4ELMNAMAPK1 | |
| SCHEMBL7285389 | 0.64 | JAK2 (0.38) | JAK2BTKKDM4EPLK1ALDH1A1 | |
| SCHEMBL11066610 | 0.63 | CHRM1 (0.40) | JAK2BTKTSHRKDM4ELMNA | |
| SCHEMBL28064638 | 0.63 | MCL1 (0.47) | JAK2BTKTSHRKDM4ENPC1 | |
| SCHEMBL23410172 | 0.63 | ALDH1A1 (0.41) | JAK2BTKTSHRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |