Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666448 | 0.83 | CA2 (0.43) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL257136 | 0.82 | KDM4E (0.64) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL20502652 | 0.80 | L3MBTL1 (0.54) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL2979262 | 0.77 | L3MBTL1 (0.46) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL13239579 | 0.77 | L3MBTL1 (0.46) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL2984205 | 0.76 | L3MBTL1 (0.55) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL1779514 | 0.76 | L3MBTL1 (0.60) | L3MBTL1PTGDR2KDM4EUBE2NHTR6 | |
| SCHEMBL13302164 | 0.75 | L3MBTL1 (0.59) | L3MBTL1PTGDR2KDM4EUBE2NHTR6 | |
| SCHEMBL2447588 | 0.74 | L3MBTL1 (0.55) | CA2CA9L3MBTL1PTGDR2KDM4E | |
| SCHEMBL2024287 | 0.74 | HTR6 (0.56) | L3MBTL1PTGDR2KDM4EUBE2NHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| EP-1996586-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007107221-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | CA2 2517/4885CA9 4281/4885L3MBTL1 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.