Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | SDHB | P21912 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29026149 | 0.85 | JAK2 (0.43) | IKBKBPDE4BPTGS1PTGS2PDE11A | |
| SCHEMBL23559758 | 0.78 | PDE4B (0.43) | IKBKBPDE4BPTGS1PTGS2PDE11A | |
| Hydrochloric Acid SCHEMBL28641939 | 0.77 | GRM2 (0.51) | IKBKBGRM2 | |
| SCHEMBL30627079 | 0.74 | TRPA1 (0.53) | — | |
| SCHEMBL23539749 | 0.73 | DYRK1A (0.44) | TGFBR1MEN1KMT2A | |
| SCHEMBL2159117 | 0.73 | MAP2K3 (0.49) | IKBKBPDE4BPDE11APDE10APDPK1 | |
| SCHEMBL945449 | 0.72 | HSP90AA1 (0.52) | PTGS1PTGS2AKR1C3AKR1C2CA1 | |
| SCHEMBL31374321 | 0.71 | PDE4B (0.38) | PDE4BPDE11APDE10ATGFBR1 | |
| SCHEMBL30627185 | 0.71 | F2 (0.42) | IKBKBPTGS1PTGS2TGFBR1CA1 | |
| SCHEMBL14955140 | 0.71 | P2RX7 (0.39) | IKBKBPDE4BPDE11APDE10ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220288064-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF | HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) | 2022-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288064-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF | PDGFRA, PDGFRB, PDGFA | IKBKB 899/4885PDE4B 309/4885PTGS1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.