Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9296210 | 1.00 | MEN1 (0.54) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9015966 | 0.92 | CPT1B (0.58) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9015965 | 0.89 | MEN1 (0.57) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9015951 | 0.82 | MEN1 (0.55) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9295816 | 0.77 | CPT1B (0.65) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9015994 | 0.77 | SMN1; SMN2 (0.59) | MEN1KMT2AKDM4EALDH1A1ALOX5 | |
| Fumaric Acid SCHEMBL29802140 | 0.77 | CPT1B (0.86) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9622306 | 0.77 | ALOX5 (0.47) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9015968 | 0.76 | LMNA (0.47) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9016004 | 0.74 | ALOX5 (0.54) | MEN1KMT2AALDH1A1LMNAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283246-A | Trimetazidine compounds | ADIR ET COMPAGNIE (FR) | 1994-02-01 | — | — | US | disclosed |