Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987127 | 0.90 | MMP2 (0.40) | MMP2MMP3SMN1; SMN2SIGMAR1 | |
| SCHEMBL2986425 | 0.83 | MMP2 (0.39) | MMP2MMP3KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2989227 | 0.82 | BCHE (0.41) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL2976840 | 0.76 | TSHR (0.49) | C3AR1KMT2ASMN1; SMN2SIGMAR1MEN1 | |
| SCHEMBL2987746 | 0.75 | KMT2A (0.46) | C3AR1KMT2ASMN1; SMN2SIGMAR1MEN1 | |
| SCHEMBL2985266 | 0.75 | KMT2A (0.47) | KMT2AMEN1 | |
| SCHEMBL2981493 | 0.73 | KMT2A (0.37) | C3AR1KMT2ASMN1; SMN2SIGMAR1MEN1 | |
| SCHEMBL4050176 | 0.72 | CCR2 (0.43) | KMT2ASIGMAR1MEN1 | |
| SCHEMBL2985326 | 0.72 | HPGD (0.50) | KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4867952 | 0.72 | CTSS (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | MMP2 2998/4885MMP3 4135/4885C3AR1 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.