Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055346 | 0.88 | ACKR3 (0.48) | KMT2AOPRM1OPRL1MEN1SIGMAR1 | |
| SCHEMBL2989227 | 0.87 | BCHE (0.41) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL4049689 | 0.83 | KMT2A (0.53) | CCR2KMT2AOPRM1OPRL1KCNH2 | |
| SCHEMBL4050182 | 0.82 | KMT2A (0.51) | KMT2AOPRM1OPRL1MEN1ADRA1D | |
| SCHEMBL4054992 | 0.82 | CCR2 (0.59) | CCR2KMT2AOPRM1OPRL1KCNH2 | |
| SCHEMBL4047391 | 0.82 | KMT2A (0.47) | CCR2KMT2AOPRM1OPRL1SIGMAR1 | |
| SCHEMBL16143663 | 0.81 | NPC1 (0.45) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL2974653 | 0.80 | SIGMAR1 (0.42) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL4048586 | 0.80 | CCR2 (0.49) | CCR2KMT2AOPRM1OPRL1KCNH2 | |
| SCHEMBL2985326 | 0.80 | HPGD (0.50) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476763-B2 | Oxo-substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |