SCHEMBL29844146

SCHEMBL29844146

C=C(Cc1nc(-c2ccc(OCCCC)c(Cl)c2)no1)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 3/20 0.50
▸ MAPT P10636 2/20 0.50
▸ LMNA P02545 1/20 0.50
▸ HTT P42858 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ HPGD P15428 1/20 0.45
▸ S1PR1 P21453 2/20 0.45
▸ GSTP1 P09211 4/20 0.44
▸ FFAR1 O14842 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23588172 1.00 TDP1 (0.50) TDP1MAPTLMNAHTTL3MBTL1
SCHEMBL23578296 0.95 S1PR1 (0.49) TDP1MAPTLMNAHTTL3MBTL1
SCHEMBL23588141 0.88 GSTP1 (0.43) MAPTLMNAL3MBTL1GSTP1FFAR1
SCHEMBL29844119 0.85 SPHK2 (0.49) S1PR1
SCHEMBL23588193 0.85 SPHK2 (0.49) S1PR1
SCHEMBL23578433 0.84 ACACB (0.57) TDP1MAPTLMNAL3MBTL1FFAR1
SCHEMBL27291369 0.82 MITF (0.43) MAPTLMNAHTTGSTP1FFAR1
SCHEMBL23578438 0.80 ACACB (0.64) TDP1MAPTLMNAL3MBTL1S1PR1
SCHEMBL31527896 0.80 FFAR1 (0.44) MAPTLMNAHTTHPGDGSTP1
SCHEMBL27291563 0.79 GSTP1 (0.41) GSTP1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN claimed
US-12617762-B2 Carboxy derivatives with antiinflamatory properties SITRYX THERAPEUTICS LIMITED (GB) 2026-05-05 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 TDP1 2097/4885MAPT 4683/4885LMNA 3388/4885
US-12617762-B2 Carboxy derivatives with antiinflamatory properties CCR1, CBR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 TDP1 1053/4885MAPT 4868/4885LMNA 1950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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