Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27186297 | 1.00 | PDK2 (0.32) | PDK2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL2179135 | 0.85 | PDK2 (0.32) | PDK2 | |
| SCHEMBL30853310 | 0.82 | LMNA (0.31) | PDK2LMNAHTTSMN1; SMN2PDK4 | |
| SCHEMBL27186160 | 0.82 | LMNA (0.31) | PDK2LMNAHTTSMN1; SMN2PDK4 | |
| SCHEMBL20840567 | 0.81 | KDM4E (0.34) | PDK2KDM4EMEN1KMT2A | |
| SCHEMBL31365128 | 0.73 | LMNA (0.38) | KDM4EMEN1KMT2ALMNA | |
| SCHEMBL22139940 | 0.73 | LMNA (0.38) | KDM4EMEN1KMT2ALMNA | |
| SCHEMBL12303154 | 0.73 | PDK2 (0.36) | PDK2PDK4YTHDC1 | |
| SCHEMBL24671925 | 0.69 | YTHDC1 (0.32) | PDK2YTHDC1 | |
| SCHEMBL23326569 | 0.69 | LRRK2 (0.32) | PDK2YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2022187266-A1 | NOVEL SUBSTITUTED BICYCLI AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |