Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.34 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856249 | 0.84 | SRD5A2 (0.47) | ALDH1A1MAPTHTTCYP19A1SMN1; SMN2 | |
| SCHEMBL29856162 | 0.82 | SLC22A12 (0.37) | LMNAALDH1A1SLC22A12EYA3MAPT | |
| SCHEMBL29856273 | 0.81 | COMT (0.40) | LMNAALOX15ALDH1A1NPSR1SLC22A12 | |
| SCHEMBL29856237 | 0.80 | MAPT (0.40) | LMNAALOX15ALDH1A1NPSR1SLC22A12 | |
| SCHEMBL29856214 | 0.79 | KDM5A (0.40) | LMNASLC22A12EYA3MAPTHTT | |
| SCHEMBL29856217 | 0.76 | TUBB4A (0.41) | LMNASLC22A12EYA3MAPTHTT | |
| SCHEMBL29856224 | 0.75 | LMNA (0.37) | LMNAALOX15ALDH1A1NPSR1SLC22A12 | |
| SCHEMBL29856234 | 0.71 | ALOX15 (0.40) | LMNAALOX15ALDH1A1NPSR1SLC22A12 | |
| SCHEMBL29856238 | 0.68 | SLC22A12 (0.43) | SLC22A12EYA3HDAC6CYP2C9HSD17B3 | |
| SCHEMBL29856192 | 0.68 | KDM5A (0.50) | SLC22A12EYA3MAPTHTTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |