Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | F13A1 | P00488 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | TGM1 | P22735 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29860367 | 1.00 | ALDH1A1 (0.34) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL25174104 | 1.00 | ALDH1A1 (0.34) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL30728859 | 0.87 | KMT2A (0.38) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL22214268 | 0.87 | KMT2A (0.38) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL29628212 | 0.87 | KMT2A (0.38) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL25174192 | 0.84 | HCAR3 (0.33) | IL1B | |
| SCHEMBL25174194 | 0.84 | HCAR3 (0.33) | IL1B | |
| SCHEMBL23559071 | 0.82 | NAMPT (0.44) | ALDH1A1NPC1MAPTMAPK1HTT | |
| SCHEMBL31267908 | 0.79 | GPR119 (0.41) | HTTKDM1A | |
| SCHEMBL31083084 | 0.77 | JAK1 (0.35) | KDM1APRMT5USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110774-A1 | PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING | Remix Therapeutics Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| WO-2021174176-A9 | PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING | REMIX THERAPEUTICS INC. (US) | 2022-09-15 | — | — | WO | disclosed |