Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.72 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.55 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 3/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24754591 | 1.00 | PGR (0.72) | PGRCDYL2CDYLTP53MAPT | |
| SCHEMBL25767723 | 0.87 | PGR (0.63) | PGRCDYL2CDYLHTR7CACNB4 | |
| SCHEMBL23835763 | 0.87 | PGR (0.63) | PGRCDYL2CDYLHTR7CACNB4 | |
| SCHEMBL5223844 | 0.84 | PGR (1.00) | PGRCDYL2CDYLHTR7 | |
| SCHEMBL2988866 | 0.81 | PGR (0.57) | PGRTP53MAPTPOLBLMNA | |
| SCHEMBL24019919 | 0.81 | PGR (0.57) | PGRTP53MAPTPOLBLMNA | |
| SCHEMBL16977576 | 0.81 | IDO1 (0.62) | PGRCDYL2CDYLTP53MAPT | |
| SCHEMBL8303268 | 0.81 | PGR (0.53) | PGRCDYL2CDYLMEN1KMT2A | |
| SCHEMBL2989569 | 0.80 | TP53 (0.62) | PGRTP53MAPTPOLBLMNA | |
| SCHEMBL2320598 | 0.80 | PGR (0.56) | PGRCDYL2CDYLTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2022-12-13 | — | — | US | disclosed |
| CN-1993324-B | 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders | EGYT GYOGYSZERVEGYESZETI GYAR | 2010-12-15 | — | — | CN | disclosed |
| US-7786129-B2 | Piperazine derivatives of dialkyl oxindoles | EGIS GYOGYSZERGYAR NYRT (HU) | 2010-08-31 | — | — | US | disclosed |
| CN-100572377-C | The indol-2-one derivates of treatment nervus centralis obstacle, gastrointestinal disorders and cardiovascular disorder | EGIS PHARMACEUTICAL WORKS (HU) | 2009-12-23 | — | — | CN | disclosed |
| US-20090281137-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | VOLK BALAZS | 2009-11-12 | — | — | US | disclosed |
| EP-1776339-B1 | 3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2009-07-01 | — | — | EP | disclosed |
| EP-1751138-B9 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2008-11-12 | — | — | EP | disclosed |
| EP-1751138-B1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-12-26 | — | — | EP | disclosed |
| US-20070232662-A1 | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders | EGIS GYOGYSZERGYAR RT. (HU) | 2007-10-04 | — | — | US | disclosed |
| US-20070232619-A1 | Piperazine Derivatives of Dialkyl Oxindoles | EGIS GYOGYSZERGYAR RT. (HU) | 2007-10-04 | — | — | US | disclosed |
| CN-101010313-A | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders | EGIS PHARMACEUTICAL WORKS (HU) | 2007-08-01 | — | — | CN | disclosed |
| CN-1993324-A | 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-07-04 | — | — | CN | disclosed |
| EP-1776339-A2 | 3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS Gyógyszergyár Nyrt (HU) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005109987-A9 | 3-(((4-PHENYL)-PIPERAZINE-1-YL)-ALKYL)-3-ALKYL-1, 3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-03-29 | — | — | WO | disclosed |
| EP-1751138-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS Gyógyszergyár Nyrt (HU) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005109987-A2 | 3-(((4-PHENYL)-PIPERAZINE-1-YL)-ALKYL)-3-ALKYL-1, 3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005108390-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232619-A1 | Piperazine Derivatives of Dialkyl Oxindoles | TPH2, DRD3, CNR2 | PGR 2399/4885CDYL2 969/4885CDYL 646/4885 |
| US-20070232662-A1 | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders | TPH2, TPH1, IDO1 | PGR 2927/4885CDYL2 2057/4885CDYL 2545/4885 |
| US-20090281137-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | TPH2, TPH1, IDO1 | PGR 2991/4885CDYL2 2027/4885CDYL 2522/4885 |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | PGR 4195/4885CDYL2 2973/4885CDYL 2300/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | PGR 3910/4885CDYL2 2474/4885CDYL 2575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.