SCHEMBL29866652

SCHEMBL29866652

[2H]C1([2H])c2cc(F)cnc2-c2cccc(N)c2N1C

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR5A P47898 1/20 0.32
PTPN11 Q06124 1/20 0.31
TGFBR1 P36897 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29136434 0.87 HTR5A (0.35) HTR5APTPN11TGFBR1
SCHEMBL30663578 0.87 HTR5A (0.35) HTR5APTPN11TGFBR1
SCHEMBL29865695 0.80 MAPT (0.32)
SCHEMBL29866682 0.79 CHRM2 (0.37)
SCHEMBL29766558 0.74 DRD4 (0.44)
SCHEMBL29866012 0.73 HTR3A (0.31)
SCHEMBL29865785 0.72 MPL (0.31)
SCHEMBL27107027 0.70 KDM4E (0.36) HTR5A
SCHEMBL29866515 0.69 MAPT (0.31)
SCHEMBL30663590 0.69 GABRG2 (0.41) PTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532485-A1 TYK2 INHIBITORS AND USES THEREOF Sudo Biosciences Limited (GB) 2025-04-09 EP disclosed
EP-4294806-A1 TYK2 INHIBITORS AND USES THEREOF Sudo Biosciences Limited (GB) 2023-12-27 EP disclosed
WO-2023227946-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2023-11-30 WO disclosed
CN-117120440-A TYK2 inhibitor and application thereof 苏多生物科学有限公司 2023-11-24 CN disclosed
WO-2022175746-A1 TYK2 INHIBITORS AND USES THEREOF SUDO BIOSCIENCES LIMITED (GB) 2022-08-25 WO disclosed