Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987708 | 0.85 | MAPK8 (0.51) | KDM4ESMN1; SMN2KMT2AMAPK8AR | |
| SCHEMBL2996795 | 0.77 | KDM4E (0.45) | KDM4ESMN1; SMN2KMT2AMAPK8AR | |
| SCHEMBL2996558 | 0.76 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2KMT2AMAPK8AR | |
| SCHEMBL8506149 | 0.72 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2AMAPK8MAPK1 | |
| SCHEMBL3000703 | 0.69 | MAT2A (0.40) | KDM4EKMT2AALDH1A1HPGDLMNA | |
| SCHEMBL2997767 | 0.69 | KDM4E (0.53) | KDM4ESMN1; SMN2KMT2AMAPK8AR | |
| SCHEMBL8504351 | 0.68 | PLA2G2A (0.52) | KDM4ESMN1; SMN2KMT2AMAPK8MAPK1 | |
| SCHEMBL6235401 | 0.67 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2AMAPK8MAPK1 | |
| SCHEMBL2996612 | 0.65 | OPRK1 (0.44) | KMT2ANPSR1 | |
| SCHEMBL2998829 | 0.65 | KMT2A (0.40) | KDM4ESMN1; SMN2KMT2AMAPK8AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781431-B2 | Thienopyrroles as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-08-24 | — | — | US | disclosed |
| US-20090036443-A1 | Thienopyrroles as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2009-02-05 | — | — | US | disclosed |
| EP-1664059-B1 | THIENOPYRROLES AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036443-A1 | Thienopyrroles as antiviral agents | ZC3HAV1, XDH, TPMT | KDM4E 3250/4885SMN1; SMN2 3684/4885KMT2A 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.