Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30707986 | 0.82 | KMT2A (0.41) | HTR6NOD2NOD1KMT2AMEN1 | |
| SCHEMBL30877525 | 0.77 | RAPGEF4 (0.51) | HTR6NOD2NOD1RAPGEF4DRD2 | |
| SCHEMBL7678499 | 0.74 | RAPGEF4 (0.56) | HTR6NOD1RAPGEF4DRD2HTR1A | |
| SCHEMBL29888845 | 0.73 | BRD4 (0.48) | HTR6NOD2NOD1DRD2HTR2A | |
| SCHEMBL29086644 | 0.73 | BRD4 (0.48) | HTR6NOD2NOD1DRD2HTR2A | |
| SCHEMBL30877392 | 0.72 | RAPGEF4 (0.48) | HTR6NOD1RAPGEF4DRD2HTR1A | |
| SCHEMBL30877437 | 0.71 | HTR6 (0.50) | HTR6RAPGEF4KMT2AMEN1ALDH1A1 | |
| SCHEMBL21590225 | 0.71 | RAPGEF4 (0.52) | HTR6NOD1RAPGEF4DRD2HTR1A | |
| SCHEMBL28458237 | 0.71 | RAPGEF4 (0.52) | HTR6NOD1RAPGEF4DRD2HTR1A | |
| SCHEMBL28561865 | 0.71 | RAPGEF4 (0.47) | HTR6RAPGEF4DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022171034-A1 | BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2022-08-18 | — | — | WO | disclosed |