Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 7/20 | 0.34 |
| ▸ | CA1 | P00915 | 7/20 | 0.34 |
| ▸ | CA2 | P00918 | 7/20 | 0.34 |
| ▸ | CA9 | Q16790 | 7/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.34 |
| ▸ | CA3 | P07451 | 3/20 | 0.34 |
| ▸ | CA4 | P22748 | 3/20 | 0.34 |
| ▸ | CA6 | P23280 | 3/20 | 0.34 |
| ▸ | CA5A | P35218 | 3/20 | 0.34 |
| ▸ | CA7 | P43166 | 3/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299045 | 0.85 | RORC (0.35) | NPC1ALDH1A1KDM4ERORCLMNA | |
| Hydrochloric Acid SCHEMBL27854459 | 0.81 | RORC (0.36) | NPC1ALDH1A1KDM4ERORCLMNA | |
| SCHEMBL299020 | 0.80 | L3MBTL1 (0.42) | NPC1ALDH1A1KDM4ECA12CA1 | |
| SCHEMBL18083205 | 0.71 | L3MBTL1 (0.43) | NPC1ALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL20377491 | 0.71 | — | — | |
| SCHEMBL298837 | 0.69 | ALDH1A1 (0.44) | NPC1ALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL17863738 | 0.69 | — | — | |
| SCHEMBL12822611 | 0.68 | L3MBTL1 (0.38) | NPC1ALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL8631834 | 0.68 | PTGS2 (0.46) | ALDH1A1KDM4ECA12CA1CA2 | |
| SCHEMBL21962138 | 0.68 | NPC1 (0.38) | NPC1ALDH1A1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018228-B2 | Nematocidal sulfonamides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-04-28 | — | — | US | disclosed |
| EP-2427058-B1 | NEMATOCIDAL SULFONAMIDES | DU PONT (US) | 2014-12-31 | — | — | EP | disclosed |
| US-20140221203-A1 | NEMATOCIDAL SULFONAMIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-08-07 | — | — | US | disclosed |
| US-8735588-B2 | Nematocidal sulfonamides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140088309-A1 | NEMATOCIDAL SULFONAMIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-03-27 | — | — | US | disclosed |
| US-8623890-B2 | Nematocidal sulfonamides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-01-07 | — | — | US | disclosed |
| US-20120114624-A1 | NEMATOCIDAL SULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-05-10 | — | — | US | disclosed |
| CN-102413693-A | Nematocidal sulfonamides | DU PONT | 2012-04-11 | — | — | CN | disclosed |
| EP-2427058-A2 | NEMATOCIDAL SULFONAMIDES | E. I. du Pont de Nemours and Company (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129500-A2 | NEMATOCIDAL SULFONAMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221203-A1 | NEMATOCIDAL SULFONAMIDES | NSFL1C, QSOX1, Q6ZSR9 | NPC1 1818/4885ALDH1A1 2283/4885KDM4E 1989/4885 |
| US-20120114624-A1 | NEMATOCIDAL SULFONAMIDES | NSFL1C, QSOX1, Q6ZSR9 | NPC1 1818/4885ALDH1A1 2283/4885KDM4E 1989/4885 |
| US-20140088309-A1 | NEMATOCIDAL SULFONAMIDES | NSFL1C, QSOX1, Q6ZSR9 | NPC1 1818/4885ALDH1A1 2283/4885KDM4E 1989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.