Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23064173 | 1.00 | POLB (0.51) | POLBHPGDMAPTHSD17B10L3MBTL1 | |
| SCHEMBL21409102 | 0.82 | POLB (0.57) | POLBHPGDMAPTHSD17B10L3MBTL1 | |
| SCHEMBL20946419 | 0.81 | GAA (0.46) | POLBHPGDMAPTHSD17B10L3MBTL1 | |
| SCHEMBL29269258 | 0.78 | CACNA1H (0.50) | L3MBTL1GRM2KDM4ENAMPTCYP1A2 | |
| SCHEMBL10165151 | 0.76 | POLB (0.52) | POLBHSD17B10L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL26932092 | 0.75 | L3MBTL1 (0.42) | MAPTHSD17B10L3MBTL1GRM2BRD4 | |
| SCHEMBL19553612 | 0.75 | HCAR3 (0.49) | HPGDMAPTHSD17B10L3MBTL1ALDH1A1 | |
| SCHEMBL30587447 | 0.75 | CHRNA7 (0.57) | KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23928856 | 0.75 | CHRNA7 (0.57) | KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3180689 | 0.75 | L3MBTL1 (0.61) | MAPTL3MBTL1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788039-B1 | FACTOR XIIA INHIBITORS | UNIV LEEDS INNOVATIONS LTD (GB) | 2026-02-11 | — | — | EP | disclosed |
| US-12336991-B2 | Factor XIIA inhibitors | UNIVERSITY OF LEEDS (GB) | 2025-06-24 | — | — | US | disclosed |
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | UNIVERSITY OF LEEDS (GB) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | F11, F13B, F12 | POLB 2428/4885HPGD 675/4885MAPT 4436/4885 |
| US-12336991-B2 | Factor XIIA inhibitors | F11, F13B, F12 | POLB 2428/4885HPGD 675/4885MAPT 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.