Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370172 | 0.89 | NR1H4 (0.39) | ALDH1A1NR1H4RXRARXRBRXRG | |
| SCHEMBL2981523 | 0.86 | NR1H4 (0.37) | ALDH1A1NR1H4ALOX15RXRARXRB | |
| SCHEMBL4346537 | 0.84 | NR1H4 (0.41) | ALDH1A1KDM4EHSD17B10NR1H4ALOX15 | |
| SCHEMBL2676114 | 0.83 | NR1H4 (0.38) | ALDH1A1NR1H4RXRARXRBRXRG | |
| SCHEMBL1022544 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL7796386 | 0.81 | NR1H4 (0.56) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL332092 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL1023382 | 0.79 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL1405888 | 0.79 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL22722988 | 0.79 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159373-B | Compound and application thereof in preparation of targeted PTL and/or NPC1L1 inhibition drugs | 青岛大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-113149930-B | Cell sugar transport channel inhibitor | 天津大学 | 2022-09-02 | — | — | CN | disclosed |
| WO-2022063071-A1 | COMPOUND AND USE THEREOF IN PREPARATION OF DRUG FOR TARGETED INHIBITION OF PTL AND/OR NPC1L1 | 青岛大学 | 2022-03-31 | — | — | WO | disclosed |
| CN-112159373-A | Compound and application thereof in preparation of PTL and/or NPC1L1 targeted inhibition drugs | 青岛大学附属医院 | 2021-01-01 | — | — | CN | disclosed |
| US-9533974-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | MICHIGAN DIAGNOSTICS, LLC (US) | 2017-01-03 | — | — | US | disclosed |
| US-20150031889-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ PAL (US) | 2015-01-29 | — | — | US | disclosed |
| US-8932881-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | GIRI BRIJ PAL (US) | 2015-01-13 | — | — | US | disclosed |
| US-8822233-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | GIRI BRIJ PAL (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140088297-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-03-27 | — | — | US | disclosed |
| US-20070225498-A1 | water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. | MICHIGAN DIAGNOSTICS, LLC | 2007-09-27 | — | — | US | disclosed |
| EP-1735621-A2 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | Giri, Brij P. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2006073424-A9 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ P (US) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006073424-A2 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ P (US) | 2006-07-13 | — | — | WO | disclosed |
| EP-1453822-A4 | DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES | GIRI BRIJ P (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-1453822-A2 | DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES | Giri, Brij P. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003054506-A2 | DEUTERIUM-BASED CHEMILUMINESCENT 1,2-DIOXETANES | GIRI BRIJ PAL (US) | 2003-07-03 | — | — | WO | disclosed |
| EP-0790991-A4 | — | — | 1997-09-03 | — | — | EP | disclosed |
| EP-0790991-A1 | NOVEL 1,2-DIOXETANE COMPOUNDS WITH HALOALKOXY GROUPS, METHODS OF PREPARATION AND USE | TROPIX, INC. (US) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015122-A1 | NOVEL 1,2-DIOXETANE COMPOUNDS WITH HALOALKOXY GROUPS, METHODS OF PREPARATION AND USE | TROPIX, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088297-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | ALDH1A1 66/4885KDM4E 1780/4885HPGD 73/4885 |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | ALDH1A1 66/4885KDM4E 1780/4885HPGD 73/4885 |
| US-20150031889-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | ALDH1A1 69/4885KDM4E 1891/4885HPGD 65/4885 |
| US-20070225498-A1 | water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. | BTD, DDT, LPO | ALDH1A1 205/4885KDM4E 3990/4885HPGD 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.