Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979074 | 0.84 | OPRL1 (0.64) | OPRM1OPRL1 | |
| SCHEMBL2991003 | 0.82 | OPRM1 (0.50) | OPRM1OPRL1POLBRAB9A | |
| SCHEMBL4074077 | 0.81 | OPRM1 (0.51) | OPRM1OPRL1NPC1RAB9A | |
| SCHEMBL4074080 | 0.78 | OPRM1 (0.51) | OPRM1OPRL1NPC1RAB9A | |
| SCHEMBL4079677 | 0.77 | OPRM1 (0.47) | OPRM1OPRL1NPC1RAB9A | |
| SCHEMBL5161128 | 0.75 | OPRM1 (0.52) | OPRM1OPRL1POLB | |
| SCHEMBL2985450 | 0.75 | OPRM1 (0.47) | OPRM1OPRL1POLBATMNAMPT | |
| SCHEMBL206971 | 0.75 | MAPT (0.49) | OPRM1OPRL1POLBATM | |
| SCHEMBL4079669 | 0.74 | OPRM1 (0.45) | OPRM1OPRL1NPC1RAB9A | |
| SCHEMBL4079674 | 0.74 | OPRM1 (0.45) | OPRM1OPRL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | OPRM1 1483/4885OPRL1 1292/4885POLB 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.