Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 5/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154899 | 1.00 | SLC40A1 (0.44) | SLC40A1CCR1NR3C1ALDH1A1TDP1 | |
| SCHEMBL6896790 | 0.89 | HSD11B1 (0.39) | SLC40A1CCR1NR3C1ALDH1A1HSD17B10 | |
| SCHEMBL1500713 | 0.86 | ALDH1A1 (0.40) | SLC40A1ALDH1A1TDP1HSD17B10KEAP1 | |
| SCHEMBL181454 | 0.84 | ALDH1A1 (0.46) | SLC40A1ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL13131553 | 0.83 | SLC40A1 (0.44) | SLC40A1CCR1NR3C1ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL7566667 | 0.82 | CA1 (0.40) | SLC40A1CCR1NR3C1ALDH1A1 | |
| SCHEMBL7528511 | 0.82 | CA2 (0.41) | SLC40A1ALDH1A1TDP1KMT2ALMNA | |
| SCHEMBL4618467 | 0.81 | SLC40A1 (0.43) | SLC40A1CCR1NR3C1ALDH1A1TDP1 | |
| SCHEMBL4440346 | 0.81 | SLC40A1 (0.43) | SLC40A1CCR1NR3C1ALDH1A1TDP1 | |
| SCHEMBL4635992 | 0.81 | SLC40A1 (0.43) | SLC40A1CCR1NR3C1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326723-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |
| WO-2022221940-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |