Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12248222 | 0.88 | KDM4C (0.54) | KDM4CPARP1KDRTSHRKMT2A | |
| SCHEMBL2933552 | 0.74 | LDHA (0.53) | SIRT6GSK3BTSHRMAPK1 | |
| SCHEMBL20852324 | 0.73 | NPC1 (0.58) | KDRKMT2AIKBKETBK1 | |
| SCHEMBL2635320 | 0.73 | SIRT6 (0.73) | SIRT6GSK3BADORA3TSHRMC4R | |
| SCHEMBL27646753 | 0.71 | P4HTM (0.49) | KDM4CSIRT6GSK3BADORA3TSHR | |
| SCHEMBL3868273 | 0.71 | P4HA1 (0.63) | KDM4CPARP1KDRHDAC1HDAC6 | |
| SCHEMBL30968251 | 0.71 | KDM4C (0.47) | KDM4CPARP1IKBKETBK1HDAC1 | |
| Hydrochloric Acid SCHEMBL27917292 | 0.71 | SIRT6 (0.70) | SIRT6GSK3BADORA3TSHRMC4R | |
| SCHEMBL28045606 | 0.70 | SIRT6 (0.44) | SIRT6GSK3BADORA3TSHRMC4R | |
| SCHEMBL7942874 | 0.69 | KDM4C (0.40) | KDM4CPARP1KDRADRA1AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |