Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.61 |
| ▸ | PARP1 | P09874 | 3/20 | 0.61 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TNKS | O95271 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821179 | 1.00 | KDM4E (0.64) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL30289849 | 0.81 | KDM4E (0.74) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL5199045 | 0.79 | TNKS2 (0.62) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL28275368 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL18934419 | 0.79 | KDM4E (0.74) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL18934416 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL47352 | 0.76 | PARP1 (1.00) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL103994 | 0.76 | QTRT1 (1.00) | ALDH1A1TNKS2PARP1QTRT1MAPT | |
| SCHEMBL6695759 | 0.75 | TNKS2 (0.81) | KDM4EALDH1A1TNKS2PARP1QTRT1 | |
| SCHEMBL11637387 | 0.74 | KDM4E (0.69) | KDM4EALDH1A1TNKS2PARP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |