Sugi Predict

Sugi Predict / Compounds / SCHEMBL3821179

SCHEMBL3821179

SCHEMBL3821179

NNc1nc2ccccc2c(=O)[nH]1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.64
▸ ALDH1A1 P00352 5/20 0.64
▸ TNKS2 Q9H2K2 4/20 0.61
▸ PARP1 P09874 3/20 0.61
▸ QTRT1 Q9BXR0 1/20 0.61
▸ RAB9A P51151 6/20 0.59
▸ MAPT P10636 7/20 0.57
▸ KMT2A Q03164 6/20 0.57
▸ MEN1 O00255 5/20 0.57
▸ SMN1; SMN2 Q16637 5/20 0.57
▸ NPC1 O15118 4/20 0.57
▸ GLA P06280 3/20 0.57
▸ HPGD P15428 2/20 0.57
▸ GAA P10253 1/20 0.57
▸ TNKS O95271 2/20 0.54
▸ PKM P14618 1/20 0.51
▸ POLB P06746 2/20 0.51
▸ LMNA P02545 2/20 0.51
▸ TP53 P04637 1/20 0.51
▸ MAPK1 P28482 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29909366 1.00 KDM4E (0.64) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL30289849 0.81 KDM4E (0.74) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL5199045 0.79 TNKS2 (0.62) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL28275368 0.79 KDM4E (0.60) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL18934419 0.79 KDM4E (0.74) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL18934416 0.77 KDM4E (0.70) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL47352 0.76 PARP1 (1.00) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL103994 0.76 QTRT1 (1.00) ALDH1A1TNKS2PARP1QTRT1MAPT
SCHEMBL6695759 0.75 TNKS2 (0.81) KDM4EALDH1A1TNKS2PARP1QTRT1
SCHEMBL11637387 0.74 KDM4E (0.69) KDM4EALDH1A1TNKS2PARP1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4226994-A BUTANOL SOLVENT, ANTHRANILIC ACID, CYANAMIDE, HYDRAZINE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-10-07 — — US claimed
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-11-27 — — US disclosed
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-12-05 — — US disclosed
EP-4445902-A2 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2024-10-16 — — EP disclosed
EP-4081305-B1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES INC (JP) 2024-09-18 — — EP disclosed
US-12054490-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-08-06 — — US disclosed
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 — — CN disclosed
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-06 — — US disclosed
US-20240139190-A1 NOVEL ANTIPARASITIC COMPOUNDS AND METHODS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2024-05-02 — — US disclosed
CN-115362003-B Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-03-22 — — CN disclosed
EP-1177195-B1 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV WARNER LAMBERT CO (US) 2003-03-19 — — EP disclosed
US-20020151558-A1 Triazolo compounds as MMP inhibitors ANDRIANJARA CHARLES (FR) 2002-10-17 — — US disclosed
WO-2002064595-A1 TRIAZOLO COMPOUNDS AS MMP INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 — — WO disclosed
EP-1177195-A1 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV WARNER-LAMBERT COMPANY (US) 2002-02-06 — — EP disclosed
WO-2000066584-A1 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV WARNER-LAMBERT COMPANY (US) 2000-11-09 — — WO disclosed
EP-0161418-B1 ANTIMICROBIAL AGENTS CONTAINING 2-(1H-PYRAZOL-1-YL)-4-(3H)-QUINAZOLINONES BAYER AG (DE) 1988-09-07 — — EP disclosed
US-4644000-A FUNGICIDES, BACTERICIDES, SLIMICIDES BAYER AKTIENGESELLSCHAFT (DE) 1987-02-17 — — US disclosed
EP-0161418-A1 Antimicrobial agents containing 2-(1H-pyrazol-1-yl)-4-(3H)-quinazolinones BAYER AG (DE) 1985-11-21 — — EP disclosed
EP-0076199-A2 Triazoloquinazolones and their salts, process and intermediates for preparing them, their use as medicines and compositions containing them ROUSSEL-UCLAF (FR) 1983-04-06 — — EP disclosed
US-4226994-A BUTANOL SOLVENT, ANTHRANILIC ACID, CYANAMIDE, HYDRAZINE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-10-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK KDM4E 1748/4885ALDH1A1 4095/4885TNKS2 497/4885
US-12054490-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK KDM4E 1748/4885ALDH1A1 4095/4885TNKS2 497/4885
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK KDM4E 1748/4885ALDH1A1 4095/4885TNKS2 497/4885
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK KDM4E 1748/4885ALDH1A1 4095/4885TNKS2 497/4885
US-20020151558-A1 Triazolo compounds as MMP inhibitors MMP8, MMP13, MMP9 KDM4E 2363/4885ALDH1A1 2221/4885TNKS2 1446/4885
US-20240139190-A1 NOVEL ANTIPARASITIC COMPOUNDS AND METHODS TUBB, TUBB1, TUBA1C KDM4E 3028/4885ALDH1A1 3602/4885TNKS2 1065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.